COVID-19 Update 67 with critical care specialist and pulmonologist Roger Seheult, MD of

After an update of global coronavirus infections and deaths, Dr. Seheult continues his review of journals and illustrates more of the possible pathway for blood clot (thrombosis) formation in COVID-19. See how oxidative stress of the endothelium (lining of the blood vessels), Von Willebrand factor, racial differences, and blood types may have a significant effect on COVID-19 severity and fatality rates.

Links referenced in this video:

Johns Hopkins –

Karger –

Pathophysiology of Haemostasis and Thrombosis –

Thrombosis Research –

Intechopen –

Science Alert –

medRxiv –

Thrombosis Journal –

Journal of Thrombosis and Haemostasis –

CDC –

Some previous videos from this series (visit MedCram.com for the full series):
-Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs – Hypertension Medications with COVID-19
-Coronavirus Pandemic Update 65: COVID-19 and Oxidative Stress (Prevention & Risk Factors)
-Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update
-Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)?
– Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)?
– Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress
– Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19?
– Coronavirus Pandemic Update 59: Dr. Seheult’s Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC)
– Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion)
– Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces?
– Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses?
– Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV:
– Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing?:
– Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse?:
– Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?:
– Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia:
– Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19:
– How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment:

Many other videos on COVID-19 (coronavirus outbreak, corona virus symptoms, influenza, coronavirus epidemic) and other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.) at MedCam.com

Speaker: Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.

MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at customers@medcram.com if you are interested)

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MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2 #Coronavirus

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  1. Hi, as someone with Von Willebrand's Disease, am I not as at risk for Covid-19 as others (since I have the opposite problem with the Von Willebrand factor and my blood doesn't clot very well)? I will still wear masks, quarantine, and social distance, but it would be a relief to know if that's the case. It would also be good to know if I'm a high risk.

    I'm not a huge science person, but from what I understand, Von Willebrand Disease and Covid-19 have polar opposite effects on the von willebrand factor. IDK if that's good or bad for me.

  2. the tent beds were said helpful. That's the impression I got.
    What other infection or disease has the same outcome? Are there compared results of treatment? Yep…fruitfresh. Indeed…..

  3. I wonder, since the paper of VWF didn't mention blood A as highest, but blood AB – while the blood type paper mentioned increased risk for blood A (but not AB), could it be that blood clots come from that the immunity defense does attack the patient's own blood if the virus have a similiarity with A antigen? (in the same way that antivirus in computers can "attack" harmless files and tag them as virus, I suspect the immune defense could in same way attack healthy things that "look" like the virus).

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  6. CAN YOU PLEASE HELP ME? I have Von willebrand disease. I watched the video but I couldn't understand because English is not my native language. Please tell me. Is the corona virus more risky for me
    ? I don't know if it matters but I use "Haemate P" as a medicine
    . PLEASE ANSWER ME!!

  7. Im o+ and none of my parents nor siblings are o+ they are either a or b. How can this be possible? Am confused! Can someone explain it to me…

  8. Thank you for distilling this knowledge.. I only wish you were around doing this in the early 70s when I was studing Physiology Final year exams I did an essay on ACE. Lovely explaination well done.

  9. Recent study states that ethnic minority population were 400% more likely to die of SARS Cov 2, even taking lifestyle, health insurance, health, age etc into account the figure was still 200% more than non ethnic population

  10. Help stop Coronavirus, do the five: 🖐
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    2. Keep a safe distance 👤…..👤
    3. Wash hands often 👏
    4. Cover your cough 😷
    5. Sick? Call ahead 👨🏻‍⚕️
    By the way, great podcast, truly one of the most interesting ways to talk about the Coronavirus. It doesn't make me bored. Good job.

  11. It is a shame you did not discuss the percentages of blood type in the Covid+ population in the study and apply these to form a better picture of risk for each blood type. For example, you state 10% of patients with AB blood type were admitted to hospital, but AB positive individuals make up, on average, only 3% of the population. This would mean that AB would appear to have an increased risk of hospitalisation when the relative percentages are taken into account. There is also a blood type distribution by country which may affect the levels of severe illness epidemiologically I would have thought. Great videos, thank you.

  12. Dr. Seheult thank you for your teachings i do not have to look for informations from different
    studies and experiments related to covid 19 and other diseases i share your lectures to other colleages  
    , excellent lectures and easy to understand , thank you for your visual aids and summarized
    the lecture after, excellent , even those who are not in the medical field find your lectures a good source of knowledge…

  13. Thank you for your excellent well explained information on Covid-19. This role of vascular endothelium dysfunction and increased vWF levels in severe Covid-19 is very interesting.

    (1) Could another possible factor in maintaining endothelial integrity and reducing vWF be reduced Magnesium levels:

    – "Magnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions"
    — Dong et al, Thromb Haemost. Mar 2008, https://www.ncbi.nlm.nih.gov/pubmed/18327408

    (2) Magnesium is also required to activate Vitamin D (and Magnesium is needed for 300 enzyme reactions, including making ATP):

    – "Low magnesium levels make vitamin D ineffective – Up to 50 percent of US population is magnesium deficient", Feb 2018, https://www.sciencedaily.com/releases/2018/02/180226122548.htm

    (3) There seems to be a deficiency of Magnesium in several European countries, especially here in the UK (which has a high Covid-19 death rate) compared to Germany. In the UK a 2013 study found that 43.8% of the over 60-year old males are under the EAR intake for Magnesium, (compared to only 3.2% under the Magnesium EAR in Germany). The UK has the highest number of Covid-19 deaths in Europe, while Germany has a much lower death rate.
    See page 15 of: https://static.cambridge.org/content/id/urn:cambridge.org:id:article:S000711451200565X/resource/name/S000711451200565Xsup001.pdf
    (which is the Supplementary data from: "Mapping low intake of micronutrients across Europe", Mensink et al, Br J Nutr. Aug 2013, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785176/ )

    Spain, France and Poland also have relatively low Magnesium intakes (although better than the UK). Calcium supplements (which are commonly prescribed to the elderly in the UK to try to reduce fractures) can reduce Magnesium absorption. The absorption of Magnesium is better from fermented foods (as otherwise phytic acid reduces absorption). Some countries, such as Poland have larger intake of fermented foods – eg.sourdough bread, pickled vegetables, etc, (as does Japan with it's popular Natto and Miso, etc). Spain, France and UK have high Covid-19 deaths per million of population. (Although perhaps this is just an association rather than a possible contributing factor) https://www.worldometers.info/coronavirus/#countries

    (4) Because only 1% of the body's Magnesium is in the blood serum, it is difficult to measure true Magnesium status. There are several methods, eg: red-cell magnesium, urinary magnesium, IV magnesium loading:

    – "Challenges in the Diagnosis of Magnesium Status", Workinger et al, Nutrients, Sep 2018, https://www.ncbi.nlm.nih.gov/pubmed/30200431

    (5) However, taking large doses of Magnesium can reduce absorption of Calcium and Zinc. And in turn larger doses of Zinc can reduce Copper and Magnesium absorption. So best to consider multiple nutrients together. There also are certain known genetic changes that influence Magnesium levels.

  14. I'm a 60 year old maintenance tech and digging these videos. They are well produced as even I can understand them and have become my source of information for this pandemic.

  15. Thank you for supporting our frequent COVID-19 updates by subscribing and visiting us at https://www.MedCram.com
    At our website, browse all of our videos and CLEAR explanations of over 60 medical topics. We also offer CMEs for medical professionals, and group rates for medical programs and institutions.
    All links referenced in this video are in the video description. Quick links to our previous updates on the coronavirus pandemic:
    – Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs – Hypertension Medications with COVID-19: https://youtu.be/OudhmwulJHY
    – Coronavirus Pandemic Update 65: COVID-19 and Oxidative Stress (Prevention & Risk Factors): https://youtu.be/gzx8LH4Fjic
    – Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update: https://youtu.be/Z2hfGcTokiY
    – Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)? https://youtu.be/Aj2vB_VITXQ
    – Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? https://youtu.be/DtPwfihjyrY
    – Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress: https://youtu.be/22Bn8jsGI54
    – Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? https://youtu.be/fn2yk5SbGiw
    – Coronavirus Pandemic Update 59: Dr. Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC): https://youtu.be/NM2A2xNLWR4
    – Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion): https://youtu.be/nO4xgcIaPeA
    – Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? https://youtu.be/2U4DAQ3kjRs
    – Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses? https://youtu.be/PgDjVEpEOdQ
    – Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV: https://youtu.be/8NffZAGELGg
    – Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing? https://youtu.be/kgzFAdYwYLM
    – Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse? https://youtu.be/o8aG63yigjA
    – Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?: https://youtu.be/qc6VV7ue4cE
    – Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia: https://youtu.be/E7MufS6dnJw
    – Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19: https://youtu.be/fya6Zwxch88
    – Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes): https://youtu.be/uaIzj3s3p4A
    – Coronavirus Pandemic Update 48: Curve Flattening in California, PPE in the ICU, Medication Trials: https://youtu.be/JN-8bGB1cLM
    – Coronavirus Pandemic Update 47: Searching for Immunity Boosters & Possible Lessons From Spanish Flu: https://youtu.be/H1LHgyfPPQ8
    – Coronavirus Pandemic Update 46: Can Hot/Cold Therapy Boost Immunity? More on Hydroxychloroquine: https://youtu.be/EFRwnhfWXxo
    – Coronavirus Pandemic Update 45: Sharing Ventilators, More on Sleep, Immunity, & COVID-19 Prevention: https://youtu.be/G1zsE9_85i4
    – Coronavirus Pandemic Update 44: Loss of Smell & Conjunctivitis in COVID-19, Is Fever Helpful? https://youtu.be/A4eu-h_owaI
    – Coronavirus Pandemic Update 43: Shortages, Immunity, & Can a TB Vaccine (BCG) Help Prevent COVID-19? https://youtu.be/LqKwAIIy-Mo
    – Coronavirus Pandemic Update 42: Immunity to COVID-19 and is Reinfection Possible? https://youtu.be/q4P91VrfPGw
    – Coronavirus Pandemic Update 41: Shelter In Place, FDA Investigates Hydroxychloroquine for COVID-19: https://youtu.be/hPz5KxgI_K4
    – Coronavirus Pandemic Update 40: Ibuprofen and COVID-19 (are NSAIDs safe?), trials of HIV medications: https://youtu.be/dT6mHi_8V5E
    – Coronavirus Pandemic Update 39: Rapid COVID-19 Spread with Mild or No Symptoms, More on Treatment: https://youtu.be/AToF8O5T86s
    – Coronavirus Pandemic Update 38: How Hospitals & Clinics Can Prepare for COVID-19, Global Cases Surge: https://youtu.be/MoisrCTu0SY
    – Coronavirus Pandemic Update 37: The ACE-2 Receptor – The Doorway to COVID-19 (ACE Inhibitors & ARBs): https://youtu.be/1vZDVbqRhyM
    – Coronavirus Pandemic Update 36: Flatten The COVID-19 Curve, Social Distancing, Hospital Capacities: https://youtu.be/vww1nIIoqmw
    – Coronavirus Pandemic Update 35: New Outbreaks & Travel Restrictions, Possible COVID-19 Treatments: https://youtu.be/vE4_LsftNKM
    – Coronavirus Epidemic Update 34: US Cases Surge, Chloroquine & Zinc Treatment Combo, Italy Lockdown: https://youtu.be/U7F1cnWup9M
    – Coronavirus Epidemic Update 33: COVID-19 Medication Treatment Trials, Global Testing Remains Limited: https://youtu.be/Mm7UrZeu-74
    – Coronavirus Epidemic Update 32: Important Data from South Korea, Can Zinc Help Prevent COVID-19? https://youtu.be/Eeh054-Hx1U
    – Coronavirus Epidemic Update 31: Mortality Rate, Cleaning Products, A More/Less Severe Virus Strain? https://youtu.be/7YI2tOoVVpk
    – Coronavirus Epidemic Update 30: More Global COVID-19 Outbreaks, Vitamin D May Aid Prevention: https://youtu.be/gmqgGwT6bw0
    – Coronavirus Epidemic Update 29: Testing problems, mutations, COVID-19 in Washington & Iran: https://youtu.be/XjEacUyp4vY
    – Coronavirus Epidemic Update 28: Practical Prevention Strategies, Patient Age vs. Case Fatality Rate: https://youtu.be/quDYb_x54DM
    – Coronavirus Epidemic Update 27: Testing accuracy for COVID-19 (CT Scan vs. RT-PCR), California Cases: https://youtu.be/xQwfuJgJ9lo
    – Coronavirus Epidemic Update 26: Treatment Updates, Stock Markets, Germany & San Francisco, Pandemic? https://youtu.be/bV1CZxJ-uvU
    – Coronavirus Epidemic Update 25: Vaccine Developments, Italy's Response, and Mortality Rate Trends: https://youtu.be/UImSVhLLeGY
    – Coronavirus Epidemic Update 24: Infections in Italy, Transmissibility, COVID-19 Symptoms: https://youtu.be/wFoj2L2LpNA
    – Coronavirus Epidemic Update 23: Infections in Kids & Pregnancy, South Korea, Spillover From Bats: https://youtu.be/JGhwAGiAnJo
    – Coronavirus Epidemic Update 22: Spread Without Symptoms, Cruise Quarantine, Asymptomatic Testing: https://youtu.be/OqpHvK0XADY
    – Coronavirus Epidemic Update 21: Antibodies, Case Fatality, Clinical Recommendations, 2nd Infections?: https://youtu.be/9BYaywITXYk
    – Coronavirus Epidemic Update 20: Misinformation Spread, Infection Severity, Cruise Ship, Origins: https://youtu.be/Ka48UZDDzLY
    – Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials: https://youtu.be/4HK9QEy1KJ8
    – Coronavirus Epidemic Update 18: Cellphone Tracking, Increase in Hospitalizations, More Sleep Tips: https://youtu.be/vE4pBkslqS4
    – Coronavirus Epidemic Update 17: Spike in Confirmed Cases, Fighting Infections with Sleep (COVID-19): https://youtu.be/wlbM6VVkVZM
    – Coronavirus Epidemic Update 16: Strengthening Your Immune Response to Viral Infections (COVID-19): https://youtu.be/qqZYEgREuZ8
    – Coronavirus Epidemic Update 15: Underreporting, Prevention, 24 Day Incubation? (COVID19): https://youtu.be/o804wu5h_ms
    – Coronavirus Epidemic Update 14: Hospital spread of infection, WHO allowed in China, N-95 masks: https://youtu.be/pDnmHu8x9C4
    – Coronavirus Epidemic Update 13: Li Wenliang, nCoV vs Influenza, Dip in Daily Cases, Spread to Canada: https://youtu.be/0UgrPgJdzp0
    – Coronavirus Epidemic Update 12: Unsupported Theories, Pneumonia, ACE2 & nCoV: https://youtu.be/GT3_A1bf9pU
    – Coronavirus Epidemic Update 11: Antiviral Drugs, Treatment Trials for nCoV (Remdesivir, Chloroquine): https://youtu.be/pfGpdFNHoqQ
    – Coronavirus Epidemic Update 10: New Studies, Transmission, Spread from Wuhan, Prevention (2019-nCoV): https://youtu.be/gPwfiQgGsFo
    – Coronavirus Epidemic Update 9: Fecal-Oral Transmission, Recovery vs Death Rate: https://youtu.be/8Hjy3UfaTSc
    – Coronavirus Outbreak Update 8: Travel Ban, Spread Outside of China, Quarantine, & MRSA: https://youtu.be/GpbUoLvpdCo
    – Coronavirus Epidemic Update 7: Global Health Emergency Declared, Viral Shedding: https://youtu.be/nW3xqcGidpQ
    – Coronavirus Outbreak Update 6: Asymptomatic Transmission & Incubation Period: https://youtu.be/UGxgNebx1pg
    – Coronavirus Update 5: Mortality Rate vs SARS / Influenza: https://youtu.be/MN9-UXsvPBY
    – How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: https://youtu.be/okg7uq_HrhQ
    – Coronavirus Update 3: Spread, Quarantine, Projections, & Vaccine: https://youtu.be/SJBYwUtB83o
    – Coronavirus Symptoms, Diagnosis, Treatment: https://youtu.be/UCG3xqtcL3c
    – Coronavirus Outbreak – Transmission & Updates: https://youtu.be/9vMXSkKLg2I