Convalescent Plasma Treatment for COVID 19 has been widespread in the US. Following infection, many patients have donated their plasma containing SARS-CoV-2 antibodies to try to help patients with severe symptoms fight COVID-19. The big news today is that the emergency approval from the FDA for the use of plasma treatment is now on hold based on a lack of robust data that demonstrates efficacy. Dr. Seheult also discusses COVID 19 in India, Brazil, North Carolina, and college campuses that have experienced coronavirus outbreaks since resuming in-person classes
(This video was recorded August 20, 2020).

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– At Home, Cheap, COVID-19 Tests with Results in 15 Minutes: How to Fix Testing with Dr. Michael Mina
-Coronavirus Pandemic Update 102: COVID 19 vs. Influenza Symptoms; Sweden; Tocilizumab; Hawaii
– COVID-19 Pandemic Update 101: T Cell Immunity vs. Antibodies & Prior Exposure to Other Coronaviruses
– Coronavirus Pandemic Update 100: Interferon Beta COVID-19 Treatment, and a Retrospective
– Coronavirus Pandemic Update 99: “Long Haulers” – Lingering & Long-Term Symptoms After COVID-19
– Coronavirus Pandemic Update 98: At Home COVID-19 Testing – A Possible Breakthrough
– Coronavirus Pandemic Update 97: Vitamin D & COVID-19 Immunity, The Endothelium, & Deficiencies
– Coronavirus Pandemic Update 96: RNA Vaccine; Ivermectin; von Willebrand Factor and COVID-19
– Coronavirus Pandemic Update 95: Widespread Clotting on Autopsy; New COVID-19 Prognostic Data
– Coronavirus Pandemic Update 94: Inhaled Steroids COVID-19 Treatment; New Pneumonia in Kazakhstan?
– Coronavirus Pandemic Update 93: Antibodies, Immunity, & Prevalence of COVID-19 – New Data from Spain
– Coronavirus Pandemic Update 92: Blood Clots & COVID-19 – New Research & Potential Role of NAC

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Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
Associate Professor at the University of California, Riverside School of Medicine

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  1. It seems this was not a test of whether or not Convalescent Plasma works, but rather, a test of the effectiveness based on concentration of antibodies (low, medium, high).

  2. ALL HUMAN'S NEED TO BE COUPLET AWARE OF THIS KILLING CORONAVIRES AS WELL AS THE HUMAN'S..🇺🇸🇺🇸📡🏩😥🐦🇬🇧 GOD BLESS THE UNITED STATE'S MARINE'S, MILITARY, AIR FORCE'S, U.S.S. ALL HOSPITAL"S, DOCTORS, SURGENS, 🇺🇸🇺🇸🙏🇺🇸🇺🇸

  3. If someone is a COVID survivor, there is a good chance they have an excellent immune system. Does that mean the plasma will provide protection for more than COVID? Will the death rate from all causes go down for the plasma receivers?

  4. I'm a infectious diseases volunteer doctor and just watched all all medcram covid-19 updates since 37th in 3 days! woohoo! 🙂 felt like back at Uni! Hats off to you dr. Seheult, I can't wait to return to my ward and start shooting all the informations I just got 🙂

  5. Universities should not be a business. Most Australian politicians had free education. Thanks for the update doc. I believe they can fight the CCP virus now and i dont believe in a vaccine but the plasma cure sounds okay.🌿

  6. Thanks for mentioning the paper-based testing… I've been wondering why we haven't been doing that from day 1. The entire point of the technology is to be cheap and rapid to develop. The core technology has been around for a while and I have no idea why it has been so difficult getting people to actually use it. Yeah, it has higher error rates, but you can always test multiple times and followup positives with more tests with a lower false-positive rate.

    Also, that Mayo study preprint you talk about… Did they do multiple comparisons correction? Seems a fair conclusion to say "nothing is statistically significant, but the pattern is promising". However, given the quite large size of the study, that also means the effect size is quite small if it is real. If convalescent plasma does indeed help, it unfortunately doesn't help that much.

  7. How about instead of looking for miracle cures, we just stay healthy. If you're diabetic, lay off the sugar. If you're overweight, get some exercise, eat less. Those two things alone will cut covid's mortality rate by half.

  8. Under intense pressure from the medical organizations around the world, US FDA spokeswoman Emily Miller later tweeted that 35 percent mentioned in trumps announcement referred to the relative difference in mortality risk between those patients in Mayos study who received a high level of antibodies against those who received a low level of antibodies.

    Dr Hahn in a tweet thread on Monday night said, I have been criticized for remarks I made Sunday night about the benefits of convalescent plasma. The criticism is entirely justified. What I should have said better is that the data show a relative risk reduction not an absolute risk reduction… However it was still not immediately clear which figures the FDA had used from the Mayo study to arrive even at this far more modest claim.

  9. 23'8'20 (3 days after Medcram's Update 103). FDA Issues Emergency Use Authorization for Convalescent Plasma as Potential Promising COVID–19 Treatment, Another Achievement in Administration’s Fight Against Pandemic. <https://www.fda.gov/news-events/press-announcements/fda-issues-emergency-use-authorization-convalescent-plasma-potential-promising-covid-19-treatment > Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for investigational convalescent plasma for the treatment of COVID-19 in hospitalized patients as part of the agency’s ongoing efforts to fight COVID-19. Based on scientific evidence available, the FDA concluded, as outlined in its decision memorandum, this product may be effective in treating COVID-19 and that the known and potential benefits of the product outweigh the known and potential risks of the product. Today’s action follows the FDA’s extensive review of the science and data generated over the past several months stemming from efforts to facilitate emergency access to convalescent plasma for patients as clinical trials to definitively demonstrate safety and efficacy remain ongoing.

  10. Hi Dr. Seheult: We developed a single score for chronic diseases based on 21 biomarkers that happen to overlap with what Harvard is doing to risk stratify in-hosptial covid patients. I believe that measuring the "cytokine rain" using surrogate markers for CSS is what is most predictive of future outcomes. We have published on this and will publish more. We have population data related to chronic disease status, but the link to covid is through the research by others that associate the markers we use. Would enjoy talking to you about it. tlewis@healthrevivalpartners.com

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